Non- animal and Animal Wound Healing Models and Assays in Current Practice

Abstract

Wound healing models are used as very important tools to test and study the new therapeutic approach in wound treatments. The present manuscript details different types of surrogates for the in vivo, human wound healing process based on different approaches (in vitro, in-vivo, ex-vivo, in-silico methods and animal models). The appropriate selection of a wound healing model is an important tool for wound healing research as it aids in the understanding of the wound healing mechanisms in detail. Also, this strategy enables the experimenter to focus on each stage of wound healing and aids in the evaluation of the wound healing methodologies in preventing the wounds; enhancing the healing process or in prevention of scar formation. The thorough understanding of the appropriate wound model will aid in evaluating the pathophysiology of the wounds, better strategies in the treatment modes, formulations for enhanced wound healing and limit abnormal scar formation. The understanding of both acute and chronic wounds healing mechanism has significantly improved by adopting these models along with the advent of new wound healing products, wound healing developments and advanced wound care.