Abstract
BackgroundNon-alcoholic fatty liver disease (NAFLD) and Helicobacter pylori (Hp) infection have a close association with an increased risk of cardiovascular disease. Metabolic dysfunction-associated fatty liver disease (MAFLD) is characterized by metabolic dysfunction in NAFLD. We investigated the synergistic effects of NAFLD/MAFLD and Hp infection on the risk of arterial stiffness in an asymptomatic population.MethodsWe included individuals who underwent abdominal ultrasonography, anti-Hp IgG antibody evaluations and cardio-ankle vascular index (CAVI) during health screening tests between January 2013 and December 2017. Arterial stiffness was defined using CAVI. A logistic regression model was used to analyze the independent and synergistic effects of NAFLD/MAFLD and Hp infection on the risk of arterial stiffness.ResultsAmong 3,195 subjects (mean age 54.7 years, 68.5% male), the prevalence of increased arterial stiffness was 36.4%. In the multivariate analysis, subjects with NAFLD but without Hp infection and those with both NAFLD and Hp infection had a significantly higher risk of increased arterial stiffness [odds ratio (OR) 1.61, 95% confidence interval (CI) 1.15–2.26, and OR 2.23, 95% CI 1.63–3.06, respectively], than subjects without Hp infection and NAFLD. Regarding MAFLD, Hp infection additively increased the risk of arterial stiffness in subjects with MAFLD (OR 2.13, 95% CI 1.64–2.78).ConclusionsAn interactive effect of Hp infection on the risk of arterial stiffness in individuals with NAFLD/MAFLD was observed. Hp infection additively increases the risk of arterial stiffness in subjects with NAFLD or MAFLD.
Highlights
Non-alcoholic fatty liver disease (NAFLD) is a substantial public health burden, with a prevalence of up to 25% of global population [1]
Helicobacter pylori (Hp) infection additively increased the risk of arterial stiffness in subjects with NAFLD or metabolic (dysfunction)-associated fatty liver disease (MAFLD)
Hp infection additively increased the risk of arterial stiffness in subjects with NAFLD/MAFLD, and the risk was higher than that of previous study with odds ratio (OR) = 2.23 and 2.13 in our study
Summary
Non-alcoholic fatty liver disease (NAFLD) is a substantial public health burden, with a prevalence of up to 25% of global population [1]. NAFLD is closely associated with various metabolic conditions, including obesity, dyslipidemia, type 2 diabetes, and cardiovascular disease [2]. In recognition of the close association between NAFLD and metabolic dysfunction, a new term “metabolic (dysfunction)-associated fatty liver disease (MAFLD)” has been introduced, and studies on its clinical significance have been conducted [4, 5]. Non-alcoholic fatty liver disease (NAFLD) and Helicobacter pylori (Hp) infection have a close association with an increased risk of cardiovascular disease. We investigated the synergistic effects of NAFLD/MAFLD and Hp infection on the risk of arterial stiffness in an asymptomatic population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
