Abstract
Over the past 10 years, it has become increasingly evident that nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects multiple extra-hepatic organ systems and interacts with the regulation of several metabolic and immunological pathways. Recent observational studies have shown that the prevalence of NAFLD is remarkably higher in psoriatic patients (occurring in up to 50 % of these patients) than in matched control subjects. Notably, psoriasis is associated with NAFLD even after adjusting for metabolic syndrome traits and other potential confounding factors. Some studies have also suggested that psoriatic patients are more likely to have the more advanced forms of NAFLD than non-psoriatic controls. The use of drug therapy in patients with a combination of NAFLD and psoriasis with the inclusion of the drug Legalon is pathogenetically justified.
Highlights
Summary Over the past 10 years, it has become increasingly evident that nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects multiple extra-hepatic organ systems and interacts with the regulation of several metabolic and immunological pathways
Recent observational studies have shown that the prevalence of NAFLD is remarkably higher in psoriatic patients than in matched control subjects
Psoriasis is associated with NAFLD even after adjusting for metabolic syndrome traits and other potential confounding factors
Summary
Резюме За последние 10 лет становится все более очевидным, что неалкогольная жировая болезнь печени (НАЖБП) является мультисистемным заболеванием, которая поражает множество органов и систем посредством метаболических и иммунологических нарушений. В некоторых исследованиях также было высказано предположение, что у пациентов с псориазом чаще встречаются более распространенные и активные формы НАЖБП, чем у лиц без псориаза. Учитывая тесную взаимосвязь метаболического синдрома как с псориазом [5, 6], так и с НАЖБП [7], неудивительно, что эти заболевания могут сосуществовать у одного и того же человека.
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