Non-AIDS defining malignancies among HIV-infected patients in a tertiary referral center in Hong Kong.

Abstract

1576Background: Non-AIDS defining malignancy (NADM) is increasingly recognized as an important cause of death among human immunodeficiency virus (HIV)-infected individuals. This study describes the details and survival trend of NADM in this group of patients in a tertiary center in Hong Kong. Methods: We have investigated the occurrence of NADM in a retrospective observational study of 1,523 HIV-infected patients. Baseline demographics, immunological data, the use of highly-active anti-retroviral therapy (HAART), details of malignancy and their treatment were analyzed. Survival was analyzed by Kaplan-Meier and Cox proportional hazards model. Results: From November 1993 to March 2013, a total of 41 NADM was diagnosed in 39 HIV-positive patients. Lung cancer, anogenital cancer, head and neck cancer, and hepatocellular carcinoma were the most common malignancies among the NADM. Compared with the 65 patients diagnosed with AIDS-defining malignancy (ADM), patients with NADM were significantly older at cancer d...