Abstract
1. Relaxations to field stimulation of sympathetic nerves were found in the guinea-pig trachea only. 2. Relaxations to field stimulation of non-adrenergic inhibitory nerves were found in the larger airways of human, monkey, guinea-pig and rabbit, but not rat. 3. Lung strips from all the mammals failed to respond to sympathetic or non-adrenergic inhibitory nerve stimulation. 4. Inhibitory β-adrenoceptors were demonstrated in the proximal airways of all species except rabbit. 5. Of the fine airways examined, β-adrenoceptors only were found in guinea-pig and α-adrenoceptors only in rabbit while rat, monkey and human tissues contained mixed populations of both receptors. 6. Adenosine is a likely candidate for the neurotransmitter in the non-adrenergic inhibitory nerves. Inhibitory receptors for adenosine were present in guinea-pig trachea although receptors for ATP are probably lacking.
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