Abstract
At present, our understanding of cerebellar glioma is still insufficient. This study collected information on patients in the SEER database to identify the predictive factors for patients with cerebellar glioma. Data from patients with cerebellar glioma diagnosed from 1975 to 2018 were retrieved from the Surveillance Epidemiology and End Results Database. We randomly divided the patients into a training group and a validation group, established a nomogram based on the training group, and used the validation group data to verify the clinical value of the model. A total of 508 patients were included in this study. Multivariate analysis was performed based on the data before randomization, and the results showed that the patient's age, WHO grade, histological type, and extent were significantly correlated with the survival rate. The C-index of the OS nomograms of the training cohort was 0.909 (95% CI, (0.880–0.938)) and 0.932 (95% CI, (0.889–0.975)) in the validation group. The calibration curve of OS for 3 and 5 years showed that there was good consistency between the actual survival probability and the predicted survival probability. For patients with cerebellar glioma, the age at diagnosis, WHO grade of the glioma, histological type, and extension are the four factors that most strongly affect the overall survival outcomes. Furthermore, our model may be a useful tool for predicting OS in these patients.
Highlights
At present, our understanding of cerebellar glioma is still insufficient
Some researchers have reported that patients with cerebellar glioblastoma have a poor prognosis, with a survival period of three to seven months[2,3], while others have observed that cerebellar glioblastoma and brain glioblastoma have similar survival times[4,5]
Kaplan–Meier curves of age, histologic type, tumour WHO grade, tumour extension, and surgery were painted to compare the overall survival of cerebellar glioma patients, as shown in Fig. 2.The results showed that age (P < 0.001), histology type (P < 0.001), WHO grade (P < 0.001), and surgery (P < 0.001) were related to the overall survival of the patients
Summary
This study collected information on patients in the SEER database to identify the predictive factors for patients with cerebellar glioma. For patients with cerebellar glioma, the age at diagnosis, WHO grade of the glioma, histological type, and extension are the four factors that most strongly affect the overall survival outcomes. Regardless of the patient’s age, histology, or pathology, cerebellar gliomas are serious neurological tumours that usually manifest as life-threatening complications, such as compression of the cerebellum and adjacent brainstem or obstruction of the cerebrospinal fluid circulation pathway, resulting in increased intracranial pressure, which leads to serious consequences and even threatens the life of the patient. We collected information on patients with cerebellar glioma from the SEER database, explored the factors that affect the overall survival time of cerebellar glioma, and constructed a clinical prognostic model of cerebellar glioma to provide risk assessment for clinical patients
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