Nomogram to predict recurrence after curative resection of pancreatic neuroendocrine tumors.

Abstract

e15654Background: Early stagenon-functioning pancreatic neuroendocrine tumors (NF-pNETs) are diagnosed more often due to improved recognition and imaging. Surgical resection is the preferred treatment, but recurrence still occurs frequently. Aim of this study is to predict recurrence after resection in order to identify patients that are at risk and might benefit from intense follow-up or adjuvant treatment. Methods: Retrospectively patients with curative resection of NF-pNET of two institutions were included. Distant metastasis, hereditary syndromes and grade 3 tumors were excluded. Recurrence was scored, defined as local tumor recurrence or new localization as lymph node- or distant metastasis. Independent predictors were identified with multivariable Cox regression. Based on hazard ratios a nomogram was developed to predict recurrence within 5-years. External validation with a retrospective cohort from a third center was performed using Harrell’s concordance index. Results: A total of 97 patients with ...