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Abstract
BackgroundSurgical site infection (SSI) is a devastating complication of orthopedic surgery, related with increased morbidity and mortality. This study was performed with the aim to compare the SSI rate in human immunodeficiency virus HIV-positive patients, to identify other risk factors for SSI and to establish a nomogram model to predict the risk of SSI.MethodsA total of 101 HIV-positive individuals following orthopedic surgery patients admitted to Beijing Ditan Hospital. Their characteristics were gathered. The univariate and multiple logistic regression analysis were performed to explore the risk factors of SSI. And the Nomogram prediction model was constructed and verified.ResultsThe independent predictive factors of SSI included CD4 (Odds ratio [OR], 0.041; P = 0.040), erythrocyte sedimentation rate (ESR) (OR, 89.773; P = 0.030), and procalcitonin (PCT) (OR, 220.746; P = 0.006). The scoring nomogram model was as follows: Logit (SSI) = − 2.63589–0.00314*CD4 < 430.75 = 1) + 0.04695*(ESR < 17.46 = 1) + 2.93694*(PCT < 0.22 = 1). The area under the Receiver Operating Characteristic (ROC) curve was 0.946. The cutoff score was − 2.1026 with a sensitivity of 93.33% and a specificity of 84.88%.ConclusionsCD4, ESR, PCT might affect the occurrence of SSI after orthopedic surgery. The nomogram model constructed in this study is helpful for predicting the probability of SSI.
Highlights
Surgical site infection (SSI) is an adverse complication of orthopedic surgery and can increase the risk of readmission [1, 2]
The risk factors of SSI based on univariate logistic regression analysis Table 2 presents the univariate Odds ratio (OR) and 95% confidence intervals (95%CI) for SSI
The OR for SSI was 0.121 in the group without basic disease compared with patients with basic disease
Summary
Surgical site infection (SSI) is an adverse complication of orthopedic surgery and can increase the risk of readmission [1, 2]. Internal fixation and implant devices are often used. Internal fixation and implant devices are kept in the body for a long time, creating space and attachments for the growth of pathogens. Does the incidence of SSI increase in the early stage of orthopedic surgery, but it increases the risk of infection in the later stage. If the internal fixation and implant devices become infected, the body must be treated with antibiotics for a long time, and the internal fixation and. Surgical site infection (SSI) is a devastating complication of orthopedic surgery, related with increased morbidity and mortality. This study was performed with the aim to compare the SSI rate in human immunodeficiency virus HIV-positive patients, to identify other risk factors for SSI and to establish a nomogram model to predict the risk of SSI
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