Abstract
The mixed radiation field produced during BNCT comprises radiations with different linear energy transfer (LET) characteristics and different efficacies in biological systems (relative biological effectiveness: RBE). The four major components of the BNCT radiation dose are: boron neutron capture (BNC) dose, gamma dose (originating primarily from neutron capture in hydrogen), fast neutron dose, and the nitrogen neutron capture (NNC) dose. Because of different attenuation of gamma rays and neutrons with various energies, the relative contributions of these components to the total dose vary with depth in tissues. In addition, the short range of BNC reaction products makes the 10B microdistribution particularly important and a compound biological effectiveness (CBE) factor must be used to express the BNC dose in photon gray-equivalent (Gy-Eq) units.1 Evaluation of the radiation doses delivered during BNCT combines data on spatial distribution of gamma and neutron fluxes, the 10B concentration and RBE/CBE factors. We report the radiation doses delivered to the tumors (post-operative contrast enhancing volumes), target volumes (tumor + a 2-cm margin), and different parts of the brains of 41 glioblastoma multiforme (GBM) patients treated with BNCT at the Brookhaven Medical Research Reactor (BMRR).2
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