Abstract
Low-dose electron microscopy of radiation sensitive biological specimens achieves only limited resolution because of the inherently weak signal buried in noise. Here, we propose to reduce the noise by using a deformable mirror similar to the Castaing–Henry device to manipulate phase of the electron waves. The method takes advantage of quantum nature of the measurement and nonrandomness of any specimen structure of interest. The simulation revealed 9.7% reduction of noise for the representative case of the ribosome. Increasingly better figures are expected as knowledge about a specimen improves.
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