Nodular lesion in the tongue: A rare case of low grade myofibroblastic sarcoma

Jefferson Tenório,Machado Orsini,Santos Dos,Frederico Medeiros

doi:10.2298/aoo190827009t

Jefferson Tenório, Machado Orsini + Show 2 more

Open Access

https://doi.org/10.2298/aoo190827009t

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Abstract

Low grade myofibroblastic sarcoma is an atypical myofibroblastic malignant neoplasm that rarely affects the oral cavity and presents a challenging histological diagnosis. Here we report the case of a 38-year-old woman who had a nodular and symptomatic lesion on the lateral border of the tongue. After the biopsy, the histopathological analysis revealed a spindle cell lesion with fascicular and storiform pattern. We performed immunohistochemical analysis that showed intense labeling for vimentin, smooth muscle actin and moderate labeling for calponin and S-100. We emphasize the rarity of low grade myofibroblastic sarcoma such as a nodular lesion on the tongue and the need for accurate diagnosis.

Highlights

Low grade myofibroblastic sarcoma (LGMS) is a malignant mesenchymal neoplasm of myofibroblastic origin that is atypical and rare and mainly affects the head and neck region (1,2)
We report a case of LGMS at right lateral border of the tongue with unusual clinical presentation, with emphasis on its clinical-pathological characteristics
The nodular fasciitis hypothesis was ruled out because it is a self-limiting reactive process characterized by proliferation of young myofibroblasts in a myxoid stroma that resembles histologically a granulation tissue or cells in culture

Summary

SUMMARY

Low grade myofibroblastic sarcoma is an atypical myofibroblastic malignant neoplasm that rarely affects the oral cavity and presents a challenging histological diagnosis. We report the case of a 38-year-old woman who had a nodular and symptomatic lesion on the lateral border of the tongue. The histopathological analysis revealed a spindle cell lesion with fascicular and storiform pattern. We performed immunohistochemical analysis that showed intense labeling for vimentin, smooth muscle actin and moderate labeling for calponin and S-100. We emphasize the rarity of low grade myofibroblastic sarcoma such as a nodular lesion on the tongue and the need for accurate diagnosis

INTRODUCTION

CASE REPORT

DISCUSSION