Abstract
Amyloidosis is the result of fibrous and insoluble amyloid protein deposition in extracellular spaces of tissues and organs, including the skin. Through the analysis of medical records, clinical condition and laboratory tests, this article proposes a rare case report of an adult patient with symptoms and diagnosis of polymyositis, histopathology of nodular amyloidosis with skin lesions suggestive of lupus. The patient is still being followed at the dermatology clinic of Valença Medical School, in order to improve the prognosis and prevent the progression of existing symptoms.
Highlights
Amyloidosis is the result of fibrous and insoluble amyloid protein deposition in extracellular spaces of tissues and organs, including the skin
This study aims to present a rare case in the literature, of an adult patient with symptoms and diagnosis of polymyositis, but with histopathological nodular amyloidosis and cutaneous lesions suggestive of lupus, in order to foster an individual and detailed investigation of each pathology, assimilating the data provided from the clinical examination and anamnesis with complementary methods
Among the amyloidosis cutaneous lesions, we can highlight those that occur as a localized primary form, being the form studied by the patient in question, so as to be evidenced by hyperemic and hypochromic macular lesions interspersed with atrophic regions and with very precise limits, of infiltrative and painful aspect located in the auricular pavilion and side portion of face
Summary
Amyloidosis is the result of fibrous and insoluble amyloid protein deposition in extracellular spaces of tissues and organs, including the skin. Through the analysis of medical records, clinical condition and laboratory tests, this article proposes a rare case report of an adult patient with symptoms and diagnosis of polymyositis, histopathology of nodular amyloidosis with skin lesions suggestive of lupus. Systemic lupus erythematosus (SLE) is a chronic, multisystem inflammatory disease of unknown cause and autoimmune nature, characterized by the presence of several autoantibodies It evolves with polymorphic clinical manifestations, with periods of exacerbations and remissions. This study aims to present a rare case in the literature, of an adult patient with symptoms and diagnosis of polymyositis, but with histopathological nodular amyloidosis and cutaneous lesions suggestive of lupus, in order to foster an individual and detailed investigation of each pathology, assimilating the data provided from the clinical examination and anamnesis with complementary methods. After being examined by the rheumatology clinic, a 58-year-old, white and male patient was referred to the dermatology outpatient clinic of the Luiz Gioseffi Jannuzzi School Hospital in the city of Valença, RJ, Brazil, with complaint of myalgia, paresthesia and paresis of the pelvic girdle, accompanied by cutaneous lesions on the scalp, face, ears, shoulder, back and neck that started approximately 3 years before with progression of the condition
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