Abstract
In hematopoietic stem cell transplantation (HSCT) the occurrence of single nucleotide polymorphisms (SNPs) within the NOD2/CARD15 gene are associated with higher susceptibility for graft-versus-host disease (GvHD). Idiopathic pulmonary syndrome (IPS) is a non-infectious early onset lung disease (<100days) after HSCT and associated with high mortality rates. Exact pathogenesis is unknown, but IPS could be considered as an allo-reactive disease. We retrospectively studied the clinical impact of NOD2-variants in pediatric HSCT patients with IPS.
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