Nocturnal short-term HRV reflects impaired daytime vigilance better than overnight HRV in suspected OSA patients.

Abstract

In obstructive sleep apnea (OSA), heart rate variability (HRV) decreases and performance in psychomotor vigilance task (PVT) worsens with more severe hypoxic load. Nevertheless, the association between HRV and PVT performance is poorly understood. Thus, we hypothesize that nocturnal short-term HRV is better related to daytime psychomotor vigilance compared to overnight HRV. To investigate this hypothesis, we retrospectively analyzed the electrocardiograms from polysomnographies of 546 consecutive patients with suspected OSA. We determined overnight HRV and short-term HRV in non-overlapping 5-minute segments and performed stepwise linear regression analyses to associate HRV with the median reaction time (RT) in the PVT. The short-term decrease in the median RR, root mean square of successive RRs, and normalized high-frequency band power were all significant (p < 0.001) indicators of longer median RTs. However, the overnight HRV parameters did not indicate worsening median RT. Instead, increased hypoxic load and N3 duration were associated with longer median RT in men but not women. The association of HRV and cardiorespiratory coupling with PVT performance was generally weak. Nocturnal short-term HRV evaluation reflected a state of vigilance better than the average overnight HRV. Thus, the overnight HRV analysis might not be optimal for patients with OSA. Utilizing the HRV analysis in a time-series manner and combined with the hypoxic load and sleep stages could bring new aspects to the health assessment of patients with OSA.