Abstract
The original reports of Neff and Petty1 that long-term domiciliary oxygen therapy could extend the life of patients with chronic bronchitis and emphysema were made in patients living at altitude in Denver. Although later studies have suggested that similar benefits can be obtained from patients living at sea level,2-5 this is yet to be confirmed by a formal controlled trial. The economic importance of chronic bronchitis and emphysema in Britain has led the Medical Research Council to establish a multicenter controlled trial of this treatment, in Birmingham, Sheffield and Edinburgh.
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