Abstract
We have examined the effects of the recently described heptadecapeptide nocistatin on K +-evoked glutamate release from rat cerebrocortical slices in vitro. In vivo, nocistatin reverses the action of nociceptin. Nocistatin (100 nM, n=7) did not inhibit K +-evoked glutamate release alone. Nociceptin (100 nM) inhibited glutamate release by 51.7±8.3% ( P<0.05, n=6) and this was fully reversed by nocistatin (100 nM). Nocistatin also appears to be an antagonist of nociceptin action in vitro.
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