Abstract
BackgroundAmbient nitrogen dioxide (NO2) is a common air pollutant in developing countries and causes skin conditions, but its effect on eczema in subtropical areas is not clear in China.ObjectTo measure the effect of short-term exposure of NO2 on the incidence of eczema and the change of outpatient visits.MethodsData of daily temperature, air pollutants, and outpatient visits from 2013 to 2018 were collected in a row. The generalized additive model (GAM) and Poisson distribution were used to assess the association between short-term exposure of NO2 and the outpatient visits of patients with eczema. The cumulative exposure effect of lag 0–3 days and the displacement effect of NO2 and other pollutants were considered as well. A single pollutant model was used to examine the independent association, and a two-pollutant model was adopted to control the confounding effect.ResultsThe daily outpatient visits of eczema increased from 75.26 to 190.85 from 2013 to 2018 (P < 0.001). The combined influence of NO2 and the related pollutant exerted a stronger influence on the incidence of eczema. The maximum effect of NO2 appeared on the exposed day.(lag 0) and disappeared on day 4 (lag 3). The children and seniors were more vulnerable to NO2 exposure.ConclusionExposure to NO2 is tightly associated with eczema incidence and outpatient visits. The hospitals should react to the visit fluctuations and adjust physician duty shifts to improve outpatient service efficiency.
Highlights
Eczema, or atopic dermatitis, is a chronic, relapsing, and severely pruritic skin disorder [1]
Exposure to NO2 is tightly associated with eczema incidence and outpatient visits
The average concentration of pollutants varied during the time: the concentration of NO2, O3, and particulate matter no greater than 10 μm (PM10) decreased from 2013 to 2016, but increased from 2017 to 2018; while PM2.5 and SO2 kept decreasing from 2013 to 2018, indicating a significant improvement in air quality
Summary
Atopic dermatitis, is a chronic, relapsing, and severely pruritic skin disorder [1]. It is a common condition at any age, affecting approximately 10–20% of children, and 2–18% of adults worldwide [2]. The possible causes of eczema include genes, dry skin, immune system or mental problems, and the most important—triggers in the environment, such as low humidity, heat, sweating, as well as air pollutants [5]. The recent studies have just expanded to the influence of nitrogen dioxide (NO2) on eczema incidence. Ambient nitrogen dioxide (NO2) is a common air pollutant in developing countries and causes skin conditions, but its effect on eczema in subtropical areas is not clear in China.
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