Abstract
NO-synthase activity and nitric oxide content in lymphoid cells of thymus and spleen of rats under conditions of diet-induced obesity
Highlights
I n recent years, the epidemic situation of overweight and obesity has been one of the most important health problems in the world
The functions of immunocompetent cells are determined by their intracellular metabolic processes, among which the key role is played by the processes of free radical oxidation and the formation of reactive oxygen species (ROS) [1]
The established imbalance in the immune system of obese patients involves the processes of maturation and differentiation of lymphocytes, increases the cytotoxic activity of immunocompetent cells, increases the expression of receptors for cytokines, activates apoptosis [9]
Summary
I n recent years, the epidemic situation of overweight and obesity has been one of the most important health problems in the world. Disorders of metabolic processes under conditions of obesity, hormonal imbalances cause an inflammatory reaction of the immune system, associated with structural and functional changes in lymphoid organs, accompanied by infiltration of immunocompetent cells, such as T cells, B-cells and macrophages into adipose tissue, and a decrease of regulatory T-lymphocytes [1]. There are structural changes in the spleen, a peripheral organ of the immune system that provides erythrocyte homeostasis, participates in hemato poiesis, metabolism, performs immunobiological, protective functions and is important in the regulation of the immune response. The functions of immunocompetent cells are determined by their intracellular metabolic processes, among which the key role is played by the processes of free radical oxidation and the formation of reactive oxygen species (ROS) [1]. Excessive free radical generation and prooxidant-antioxidant balan ce are among the causes of nitric oxide synthase (NOS) activation and nitric oxide (NO) hyperpro-
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