NO, ROS, RAS, and PVAT: More Than a Soup of Letters.

Clarissa Germano Barp,Daniella Bonaventura,Jamil Assreuy

doi:10.3389/fphys.2021.640021

Abstract

Perivascular adipose tissue (PVAT) has recently entered in the realm of cardiovascular diseases as a putative target for intervention. Notwithstanding its relevance, there is still a long way before the role of PVAT in physiology and pathology is fully understood. The general idea that PVAT anti-contractile effect is beneficial and its pro-contractile effect is harmful is being questioned by several reports. The role of some PVAT important products or systems such as nitric oxide (NO), reactive oxygen species (ROS), and RAS may vary depending on the context, disease, place of production, etc., which adds doubts on how mediators of PVAT anti- and pro-contractile effects are called to action and their final result. This short review will address some points regarding NO, ROS, and RAS in the beneficial and harmful roles of PVAT.

Highlights

Since the pioneering work of Soltis and Cassis (1991), perivascular adipose tissue (PVAT) has been recognized as an active player in vascular physiology and pathology
As for the mechanisms involved in PVAT renin–angiotensin system (RAS) anti-contractile effects, ANG-(1–7) released by PVAT acts by Mas receptor on endothelial cells, releasing nitric oxide (NO) and leading to relaxation of the blood vessels (Lee et al, 2009, 2011; Lu et al, 2011b)
PVAT has a global anti-contractile effect that can be seen in different vessels such as the aorta and mesentery arteries, as well as in veins

Summary

Introduction

Since the pioneering work of Soltis and Cassis (1991), perivascular adipose tissue (PVAT) has been recognized as an active player in vascular physiology and pathology. As for the mechanisms involved in PVAT RAS anti-contractile effects, ANG-(1–7) released by PVAT acts by Mas receptor on endothelial cells, releasing NO and leading to relaxation of the blood vessels (Lee et al, 2009, 2011; Lu et al, 2011b).

Results

Conclusion