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Abstract
BackgroundSalivary α-amylase (sAA) activity alternations are observed in major depressive disorder (MDD) being associated with depression severity and its specific psychopathological dimensions with anxiety being attributed to distress. No data is available on sAA in MDD according to Hamilton Rating Scale for Depression (HAMD-17) and State-Trait Anxiety Inventory (STAI). The exploratory study examines whether and to what extent baseline sAA level is interrelated to the psychopathological features including severity of symptoms and specific psychopathological dimensions.Material and MethodsThe basal, non-stimulated sAA activity was studied in 20 non-late-life adult, treatment-naïve MDD patients with short-illness-duration and in 20 age- and sex-matched healthy controls along with psychometric assessments with Hamilton Rating Scale for Depression (HAMD-17) and Spielberger State-Trait Anxiety Inventory (STAI).ResultsSignificantly lower (p=0.011) sAA activity was observed in MDD as compared to controls. No significant correlations were observed between sAA activity and the total HAMD-17 score as well as with regard to the specific core depression, insomnia, anxiety and somatic HAM-D psychopathological dimensions. No significant correlations were also found between sAA and STAIX-1 and STAIX-2 scores.ConclusionsLow baseline sAA levels in MDD with no correlations between sAA and psychopathological features including severity of symptoms and specific psychopathological dimensions was found. Key words:Salivary alpha-amylase, major depressive disorder, Spielberger State-Trait Anxiety Inventory, Hamilton Rating Scale for Depression.
Highlights
Major depressive disorder (MDD) is often associated with an altered monoamine neurotransmission accompanied by hypothalamic-pituitary-adrenal (HPA) axis dysfunction and autonomic nervous system (ANS) maladaptive activation, being all associated with chronic stress
There were no significant differences in terms of gender, age, BMI or WHR between major depressive disorder (MDD) patients and controls with none of these factors being significantly associated with Salivary α-amylase (sAA)
No significant correlations were found between sAA activity and STAIX-1 and STAIX-2 scores (Table 1)
Summary
Major depressive disorder (MDD) is often associated with an altered monoamine neurotransmission accompanied by hypothalamic-pituitary-adrenal (HPA) axis dysfunction and autonomic nervous system (ANS) maladaptive activation, being all associated with chronic stress. We demonstrated low baseline sAA in drugnaïve patients with short-illness-duration first episode MDD where sAA activity was not significantly correlated neither with duration nor the severity of depressive symptoms as measured by the total HAMD-17 score [5]. This exploratory study was undertaken to examine whether and to what extent sAA activity is interrelated to the psychopathological features of MDD including severity of symptoms and specific psychopathological dimensions in baseline non-stimulated conditions. Salivary α-amylase (sAA) activity alternations are observed in major depressive disorder (MDD) being associated with depression severity and its specific psychopathological dimensions with anxiety being attributed to distress. Conclusions: Low baseline sAA levels in MDD with no correlations between sAA and psychopathological features including severity of symptoms and specific psychopathological dimensions was found
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