Abstract
Traumatic brain injury (TBI) impacts about 42 million people per year and is especially common among veterans and individuals experiencing homelessness. In fact, TBI is two to seven times more prevalent among those experiencing homelessness than the general population. Despite this significant clinical burden, effective treatments for TBI remain a major unmet clinical need among this unique patient population. Although neuroinflammation has been recognized as a key contributing factor to TBI pathology, we hypothesize that individuals experiencing homelessness likely display even greater neuroinflammation following TBI due to exacerbated stress of daily living. Thus, we explain the pathophysiology of neuroinflammation in TBI and homelessness and propose the necessity of including this unique population in novel therapy developments, such as stem cell transplantation.
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