Abstract
( R)-8-Hydroxy-2-(di- n-propylamino)tetralin (8-OH-DPAT) depressed the monosynaptic reflex. This effect was not antagonized by 5-HT 1A receptor antagonists. We examined whether 5-HT 1D and 5-HT 7 receptors are involved in ( R)-8-OH-DPAT-induced inhibition of the monosynaptic reflex in spinalized rats. Pretreatment with methiothepin and mesulergine, but not clozapine, inhibited ( R)-8-OH-DPAT-induced monosynaptic reflex depression. Pretreatment with 2 a-(4-phenyl-1,2,3,6-tetrahydropyridal)butyl)-2 a,3,4,5-tetrahydrobenzo[ c, d]indol-2(1 H)-one (DR4004) and ( R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrolidine (SB-269970), new selective 5-HT 7 receptors antagonists, and N-[methoxy-3-(4-methyl-l-piperazinyl)phenyl]-2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1-biphenyl]-4-carboxamide (GR127935), a selective 5-HT 1D receptor antagonist, had no effect on ( R)-8-OH-DPAT-induced depression. These results suggested that 5-HT 7 and 5-HT 1D receptors are not involved in ( R)-8-OH-DPAT-induced monosynaptic reflex depression.
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