Abstract
Recent reports suggest that heroin and its metabolite morphine 6β-glucuronide can produce analgesia independent of the morphine-preferring μ-opioid receptor. We have tested heroin and morphine 6β-glucuronide analgesia in wild-type, homozygous and heterozygous μ-opioid receptor knockout mice. Homozygotes display no heroin or morphine 6β-glucuronide analgesia. Heterozygous mice with one μ-opioid receptor gene copy reveal reduced heroin and morphine 6β-glucuronide analgesia. The μ-opioid receptor-dependence of heroin and morphine 6β-glucuronide fails to support a requirement for a heroin-specific opiate receptor subtype.
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