Abstract
BackgroundThe hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy. We investigated tumor lung tissues from five patients with former BAC histology using high-throughput sequencing technologies to discover potential viruses present in this type of lung cancer. Around 180 million single reads of 100 bases were generated for each BAC sample.ResultsNone of the reads showed a significant similarity for Jaagsiekte sheep retrovirus (JSRV) and no other viruses were found except for endogenous retroviruses.ConclusionsIn conclusion, we have demonstrated the absence of JSRV and other known human viruses in five samples of well-characterized lepidic adenocarcinoma.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-015-1669-8) contains supplementary material, which is available to authorized users.
Highlights
The hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy
The hypothesis of an infectious etiology of the formerly named “BACs” has raised controversy, which has been reopened by the observation that the ovine pulmonary adenocarcinoma, which shows some strong clinical and histological similarities with human “BACs”, is associated causally to the infection by the JSRV retrovirus (Jaagsiekte sheep retrovirus) [2–5]
Tumor samples Frozen tumor lung tissues were retrospectively collected from five patients with former “BAC” histology treated at the Institut Mutualiste Montsouris (Paris, France) between 2007 and 2011
Summary
The hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy. The international WHO 2015 classification recommends distinguishing adenocarcinoma in situ (AIS, formerly non-mucinous BAC) from invasive mucinous adenocarcinoma (IMA, formerly mucinous BAC) and non-mucinous lepidic predominant invasive adenocarcinoma of the lungs [1]. In many such patients, the tumor progression respects the pulmonary architecture and develops mainly in the terminal respiratory unit (lepidic growth). The hypothesis of an infectious etiology of the formerly named “BACs” has raised controversy, which has been reopened by the observation that the ovine pulmonary adenocarcinoma, which shows some strong clinical and histological similarities with human “BACs”, is associated causally to the infection by the JSRV retrovirus (Jaagsiekte sheep retrovirus) [2–5]. In humans, molecular approaches mainly based on PCR technology aiming to reveal the genome of the JSRV virus in the patients with a bronchiolar-alveolar
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