Abstract
Better intervention strategies for patients with treatment-resistant depression are greatly needed. McIntyre and colleagues1 set out to investigate the effectiveness of intravenous (IV) ketamine through a chart review of 201 such outpatients that all received four IV ketamine infusions over one-to-two weeks. They concluded that IV ketamine was effective in treating anxiety, irritability, agitation (AIA) and suicidal ideation (SI) in adults with treatment-resistant mood disorders and suggested IV ketamine should be considered a treatment alternative for adults with affective disorders presenting with mixed features in addition to suggesting a need for a randomized trial based on their findings.
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