Abstract
An immunological cross-reaction between histones and the encephalitogenic myelin basic protein (MBP) of brain white matter has been discussed repeatedly. The binding ability of the histones Fl, F2a1, F2a2, F2b and F3, isolated from calf thymus, and of the F2c fraction of chicken erythrocytes to antibodies against human MBP was examined using a radioimmunological technique with high sensitivity. There was no evidence for any immunological cross-reaction between these closely related basic proteins, neither by the direct binding test of labelled histones to the antibodies to MBP, nor by the binding inhibition test of MBP to its antibodies in presence of excessive amounts of histones.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International archives of allergy and applied immunology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
