Abstract
Background and Aims : Clonal hematopoiesis (CH) is emerging as a new risk factor for atherosclerotic cardiovascular disease (CVD) and PPM1D is among the most commonly mutated genes in CH. Mutations in PPM1D are overrepresented in cancer survivors, and human and mouse studies support that the clonal expansion of PPM1D mutant hematopoietic cells is facilitated by cytotoxic cancer therapies. The aim of this study was to assess the role of PPM1D mutations on atherosclerosis development in a mouse model of radiation-related CH.
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