Abstract
To investigate the effect of a musical intervention on neonatal stress response to venepuncture as measured by salivary cortisol levels and pain profile scores. In a randomised control crossover trial, participants were randomised to both a control arm (sucrose) and intervention arm (sucrose and music) for routine venepuncture procedures. Salivary swabs were collected at baseline, 20minutes post-venepuncture and 4hours post-venepuncture. Pain levels were assessed using the Premature Infant Pain Profile (PIPP). A total of 16 preterm neonates participated in both arms to complete the study. Cortisol values were elevated at all timepoints in the intervention arm (baseline, 20minutes, and 4hours post-procedure) but not significantly so (P=.056, P=.3, and P=.575, respectively). Median change in cortisol values from baseline was +128.48pg/mL (-47.66 to 517.02) at 20minutes and +393.52pg/mL (47.88-1221.34) at 4hours post-procedure in the control arm compared to -69.564pg/mL (-860.96 to 397.289) and +100.48pg/mL (-560.46 to 842.99) at 20minutes and 4hours post-procedure in the intervention arm. There was no statistically significant difference observed between groups (P=.311 at 20minutes, and P=.203 at 4hours post-procedure). PIPP scores were not significantly different between study arms. Our findings did not support the additional benefit of music intervention on neonatal stress response to venepuncture in preterm infants.
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