Abstract
KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. We recruited 100 healthy young volunteers, including 53 TT carriers and 47 C allele carriers. No differences were detected between the TT homozygotes and C-allele carriers for any diffusion and kurtosis parameter. These results indicate KIBRA rs17070145 polymorphism likely has little or no effect on brain microstructure in young adults.
Highlights
KIBRA gene, known as WWC1 gene located on chromosome 5q35.1, was first described in 2003 [1]
100 healthy young Chinese Han subjects with highquality imaging data and KIBRA genotypic information were included in this study
These subjects were divided into two groups including 53 TT homozygotes and 47 C-allele carriers (37 CT and 10 CC carriers) according to the KIBRA genotypes which was consistent with the previous studies [19, 28]
Summary
KIBRA gene, known as WWC1 gene located on chromosome 5q35.1, was first described in 2003 [1]. KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. No differences were detected between the TT homozygotes and C-allele carriers for any diffusion and kurtosis parameter.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
