NO DIFFERENCE OF SERUM IL-6 LEVEL AMONG DIPPER AND NON DIPPER HYPERTENSIVE PATIENTS

Abstract

Background: A non-dipping BP profile is currently regarded as a risk factor for cardiovascular events and target organ damage. Mechanism explaining the relationship between hypertension and target organ damage is inflammation. IL-6 is a key mediator of this inflammatory process. Objective: To investigate serum IL-6 level in dipper and non dipper hypertensive patients. Method: Forty-eight hypertensive patients were recruited. Blood pressure was measured by 24 hours ambulatory blood pressure monitor. The presense of dipping/nondipping and Morning Blood Pressure Surge (MBPS) also considered in spite of achieving blood pressure target throghout the day. Serum level of interleukin-6 (IL-6) were measured by ELISA Result: Controlled hypertensive patients were found in 47.9% of total subjects. 85.41% of total subjects had dipping blood pressure pattern and 12.5% of total subjects had MBPS. IL-6 level in controlled and uncontrolled hypertension was 74.57 ± 76.47 pg/ml and 75.80 ± 67.27 pg/ml, respectively. Moreover, IL-6 level in dipper and non dipper hypertensive patients was 67.59 ± 66.65 pg/ml and 76.51 ± 72.48 pg/ml, respectively. Furthermore, IL-6 level in subjects with MBPS and non MBPS were 86.1 ± 63.10 pg/ml and 73.65 ± 72.67 pg/ml, respectively. There were no significant difference of IL-6 serum level between controlled and uncontrolled hypertensive patients (p = 0.688), dipper and non dipper hypertensive patients (p = 0.599), and MBPS and non MBPS hypertensive patients (p = 0.489). Conclusion: None of the dipping pattern, MBPS, and blood pressure control correlate with serum IL-6 levelincrease.