No Diagnostic Value of Plasma Clusterin in Alzheimer's Disease

Edina Silajdžić,Lennart Minthon,Maria Björkqvist,Oskar Hansson,Gianluigi Forloni

doi:10.1371/journal.pone.0050237

Edina Silajdžić, Lennart Minthon + Show 3 more

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https://doi.org/10.1371/journal.pone.0050237

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Journal: PloS one	Publication Date: Nov 28, 2012
Citations: 65	License type: CC BY 4.0

Affiliation: Lund University, Skåne University Hospital

Abstract

There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation.

Highlights

As populations get older, the prevalence of Alzheimer’s disease (AD), the major cause of dementia, will increase considerably during the coming decades [1]
Biomarkers are, urgently needed to correctly identify subjects affected by AD before they have developed dementia and to track disease progression in AD [4]
Clusterin plasma levels did not differ between controls and patients with AD, DLB, VaD, FTD or PDD

Summary

Introduction

The prevalence of Alzheimer’s disease (AD), the major cause of dementia, will increase considerably during the coming decades [1]. Biomarkers are, urgently needed to correctly identify subjects affected by AD before they have developed dementia and to track disease progression in AD [4]. Known as apolipoprotein J, is a multifunctional lipoprotein involved in amyloid-b (Ab) fibrillisation and clearance [8], [9] complement inhibition [10], [11] and neuronal apoptosis [12], [13]. Clusterin is expressed in many tissues but the expression is high in the brain [14]

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