Abstract
PURPOSE: Ambrisentan is an oral, once-daily, ETA-selective endothelin receptor antagonist that is approved for the treatment of pulmonary arterial hypertension (PAH) in patients with WHO class II or III symptoms. Tadalafil is an oral, once-daily, phosphodiesterase type 5 (PDE-5) inhibitor currently under investigation for the treatment of PAH. Concomitant use of these two oral, once-daily therapies for PAH may be likely; therefore, this study was designed to assess the potential for pharmacokinetic (PK) interactions between ambrisentan and tadalafil.
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