Abstract
Nitric oxide (NO) is a cytoprotective molecule and may act via the cGMP–protein kinase G signalling pathway activating the soluble-guanylate-cyclase (GC). The B-type natriuretic peptide (BNP) activates the particular GC and probably acts via the same pathway. The aim of the present study was the exploration of the downstream signalling pathway of cGMP signalling. Therefore, primary cardiomyocyte cultures prepared from newborn rats were subjected to normoxic as well as 3 h hypoxia and 2 h reoxygenation protocols, respectively.
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