Abstract
This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients. A total of 200 NSCLC patients and 200 healthy controls with matched age and gender were recruited for genotyping of XRCC1 SNPs (rs2256507 and rs1001581) and CLPTM1L SNPs (rs401681 and rs4975616). Association of these SNPs with NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age. The frequencies of genotype and allele in these four loci (rs2256507, rs1001581, rs401681, and rs4975616) were not significantly different between the cases and controls, or between either of the histological subgroups (adenocarcinoma and squamous cell carcinoma) and controls. Although these SNPs are associated with NSCLC risk in patients with a tobacco-smoking habit, this study demonstrated that XRCC1 and CLPTM1L gene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms of NSCLC betwee tobacco smokers and non-smokers may be different. Future studies are needed to uncover the underlying molecular mechanisms for NSCLC in non-smokers.
Highlights
Lung cancer is a leading cause of cancer-related death in the world (Siegel et al, 2013)
Conclusions: these single nucleotide polymorphisms (SNPs) are associated with non-small cell lung cancer (NSCLC) risk in patients with a tobacco-smoking habit, this study demonstrated that x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) gene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms of NSCLC betwee tobacco smokers and non-smokers may be different
The data showed that there is no association between SNPs and NSCLC risk in never smokers and this is the first study in a Chinese population to show this patten
Summary
Lung cancer is a leading cause of cancer-related death in the world (Siegel et al, 2013). Recent genome-wide association studies have shown that polymorphisms of rs2256507 and rs1001581 in x-ray repair cross-complementing group 1 (XRCC1) were significantly associated with the increased risk of non-small cell lung cancer (NSCLC) among Latinos but not among African-Americans (Chang et al, 2009), and the SNPs of Cleft Lip and Palate Transmembrane Protein 1-Like (CLPTM1L) rs401681 (Pande et al, 2011) was associated with decrease in lung cancer risk in Caucasians. This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients. Future studies are needed to uncover the underlying molecular mechanisms for NSCLC in non-smokers
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