Abstract
Anti-myelin IgGs occur in the cerebrospinal fluid (CSF) and serum of multiple sclerosis (MS) patients, and can induce inflammatory effector functions in leukocytes by crosslinking IgG receptors (FcγR). The efficiency of FcγR-mediated inflammatory processes is affected by functional polymorphisms of three Fcγ receptors (FcγRIIa, FcγRIIIa, FcγRIIIb). The relevance of FcγR polymorphisms in MS was evaluated by studying the distribution of FcγRIIa, FcγRIIIa and FcγRIIIb genotypes in 432 MS patients and 515 healthy controls. No significant differences were found between MS patients and controls, or between subgroups of patients. We conclude that Fcγ receptor polymorphisms influence neither susceptibility nor clinical disease course of MS.
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