Abstract
No Association of Chronic Cerebrospinal Venous Insufficiency with Multiple Sclerosis.
Highlights
Subsequent to the initial reports by Zamboni et al, prevalence studies of Chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) have reported conflicting results.[2,3,4] Importantly, some studies have found a very low prevalence of CCSVI,[5,6,7,8] suggesting that the ultrasound assessments in those studies were conducted very differently from the original reports.[9]
The incidence of subjects meeting CCSVI criteria was determined using two interpretations of the ultrasound assessments, which differed in the way criteria 2 and 3 were analyzed
There was no significant difference in CCSVI between MS and controls
Summary
Subsequent to the initial reports by Zamboni et al, prevalence studies of CCSVI in MS have reported conflicting results.[2,3,4] Importantly, some studies have found a very low prevalence of CCSVI,[5,6,7,8] suggesting that the ultrasound assessments in those studies were conducted very differently from the original reports.[9] We assessed the prevalence of CCSVI in both MS and non-MS populations, utilizing standardized ultrasound methodology and blinded evaluators
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