Abstract
BackgroundMany published studies have estimated the association between the +331G/A (rs10895068) polymorphism in the progesterone receptor (PgR) gene and breast cancer risk. However, the results remain inconsistent and controversial. To address this inconsistency, we systematically interrogated the aforementioned association via a meta-analysis.MethodsThrough a literature search, we identified 13 case-control studies, including 12,453 cases and 14,056 case-free controls. The strengths of reported associations were evaluated using odds ratios (ORs) with 95% confidence intervals (95%CIs).ResultsAn association was found between +331G/A polymorphism and +331G/A risk in the dominant model (p = 0.027). Via subgroup analysis, we found no association between +331G/A and breast cancer risk in Caucasians, Asians or mixed racial groups.ConclusionsThrough meta-analysis, we were able to gain insight into previously reported associations between +331G/A polymorphism and breast cancer risk. However, further studies are still needed to provide more evidence.
Highlights
Many published studies have estimated the association between the +331G/A polymorphism in the progesterone receptor (PgR) gene and breast cancer risk
Inclusion and exclusion criteria Included studies met the following criteria: (1) casecontrol design; (2) clinical trial evaluating associations between +331G/A gene polymorphisms and breast cancer susceptibility; (3) pathological confirmation of breast cancer diagnosis was reported for all patients; (4) data regarding sample size and individual genotype frequencies were available for all cases and controls; and (5) at least two comparison groups were included
We performed the online search of multiple databases for available studies reporting associations between PgR +331G/A polymorphisms and breast cancer risk
Summary
Many published studies have estimated the association between the +331G/A (rs10895068) polymorphism in the progesterone receptor (PgR) gene and breast cancer risk. To address this inconsistency, we systematically interrogated the aforementioned association via a meta-analysis. The most common malignant neoplasm in women, breast cancer has a higher developed versus developing countries. It is a complex and multi-factorial disease caused by a combination of genetic and environmental factors. Primary breast tumors which lack PR are more prone to develop secondary sites than tumors which express PR in those postmenopausal patients [9]. This suggests that PR may limit breast cancer progression
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