Abstract
TGFBR1*6A, a functionally polymorphic allele in the transforming growth factor [beta] receptor 1 gene (TGFBR1), has been hypothesized to increase risk of various cancers. However, little has been documented about connection of this variant with lung cancer. In an attempt to explore whether the TGFBR1*6A is associated with lung cancer, we performed genotyping followed by sequencing in 252 patients with lung cancer and 250 healthy controls. The frequency for the heterozygote 9A/6A is 13.9% in cases compared with 12.4% in controls, and the odds ratio is 1.14 (95% confidence interval: 0.68-1.91), which is not statistically significant (p = 0.62), suggesting that TGFBR1*6A could not be a cancer susceptibility factor for Chinese patients with lung cancer. We have no evidence to support the hypothesis that TGFBR1*6A is associated with lung cancer.
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