Abstract
Available evidence linking serum uric acid (SUA) and bone mineral density (BMD) remains controversial, and data on this association are limited among adult men in the general population. Thus, the aim of this study was to evaluate the association of SUA with lumbar spine BMD in US adult males. A cross-sectional study was conducted based on the National Health and Nutrition Examination Survey (NHANES, 1999–2006) database. Multivariate linear regression analyses were employed to assess the association of SUA with lumbar spine BMD, considering complex survey design and sampling weights. Through rigorous eligibility criteria, a total of 6704 individuals were yielded for final data analysis (average age, 40.5 years; 70.6% white). After fully adjusting potential confounders, no associations were detected between SUA and lumbar spine BMD [β (95% confidence interval, CI), − 0.003 (− 0.007, 0.002)]. Additionally, similar results were observed in all stratification analyses, and no interactions were found based on all priori specifications. In brief, our findings did not provide an inspiring clue for the hypothesis that SUA may be beneficial to lumbar spine BMD. Future more prospective studies are needed to further explore the causal relationship of SUA with lumbar spine BMD.
Highlights
Available evidence linking serum uric acid (SUA) and bone mineral density (BMD) remains controversial, and data on this association are limited among adult men in the general population
No interactions were observed based on all priori stratification. In this nationally representative population of US adult men, SUA was not statistically significantly associated with lumbar spine BMD. This association was independent of other factors related to bone health, such as age, race/ethnicity, dietary factors, body mass index (BMI), eGFR, serum calcium, serum phosphorus, 1,25D, and parathyroid hormone (PTH)
None of priori stratifications modified the association of SUA with lumbar spine BMD (P for interaction > 0.05)
Summary
Available evidence linking serum uric acid (SUA) and bone mineral density (BMD) remains controversial, and data on this association are limited among adult men in the general population. After fully adjusting potential confounders, no associations were detected between SUA and lumbar spine BMD [β (95% confidence interval, CI), − 0.003 (− 0.007, 0.002)]. Most studies exploring the relationship of SUA with lumbar BMD focused on peri- and post-menopausal women, or elderly men[13,14,15,16], but this association in general adult men remains limited and equivocal. We used data from the nationally representative NHANES (1999–2006) database, through rigorous inclusion criteria as well as fully adjusting confounding factors, to examine the association of SUA with lumbar spine BMD among US adult males
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