Abstract
Previous epidemiologic studies have revealed a possible association between microRNA-608 rs4919510 G>C polymorphism and digestive system cancers (DSCs) risk, but the results were not consistent. We therefore performed an updated meta-analysis to explore the association between microRNA-608 rs4919510 G>C polymorphism and DSCs risk. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the relationship between the microRNA-608 rs4919510 G>C polymorphism and DSCs risk. Heterogeneity, cumulative analyses, sensitivity analyses, and publication bias were also conducted to examine the statistical power. Eight published articles with nine independent case-control studies involving 10,836 individuals were included in this meta-analysis. Overall, no significant association was found between microRNA-608 rs4919510 G>C polymorphism and DSCs risk in general populations. But some significant protective effects were observed in the subgroup of Caucasian population group in three genetic models (C vs. G: OR = 0.82, 95% CI, 0.68–0.99, P = 0.03, I2 = 0%; CC vs. GG: OR = 0.59, 95% CI = 0.36–0.97, P = 0.04, I2 = 0%; GC+CC vs. GG: OR = 0.61, 95% CI = 0.37–0.99, P = 0.05, I2 = 0%). In summary, current evidence indicates that the microRNA-608 rs4919510 G>C polymorphism maybe an important factor of DSCs susceptibility, especially in Caucasian population.
Highlights
Digestive system cancers (DSCs), which comprise esophageal cancer (EC), gastric cancer (GC), hepatocellular cancer (HC), pancreatic cancer (PC) colorectal cancer (CRC) and other solid carcinoma, is one of the most common malignancies with increasing incidence and mortality worldwide (Torre et al, 2015)
Five studies focused on colorectal cancer(Ryan et al, 2012; Zhang, 2012; Kupcinskas et al, 2014a; Ying et al, 2016), two studies focused on gastric cancer (Kupcinskas et al, 2014b; Jiang et al, 2016), one study focused on hepatocellular cancer (Wang et al, 2014) and other focused on esophageal cancer (Zhang et al, 2015)
MicroRNA-608 is novel small RNA that has been shown to be significantly associated with cancer development, metastasis and recurrence
Summary
Digestive system cancers (DSCs), which comprise esophageal cancer (EC), gastric cancer (GC), hepatocellular cancer (HC), pancreatic cancer (PC) colorectal cancer (CRC) and other solid carcinoma, is one of the most common malignancies with increasing incidence and mortality worldwide (Torre et al, 2015). Radiotherapy, chemotherapy and other treatments may cause extensive damage to patients’ tissues and organs and may result in various complications that lead to local dysfunction and seriously decrease the quality of life of patients (Nederlof et al, 2016; Bosch et al, 2017; Motoyama et al, 2017). No clear explanation of the mechanism underlying DSCs development and the susceptibility of different patients exist. Some researches indicate that unhealthy life styles, cigarette and alcohol use, viral infection, local inflammation and stress can trigger DSCs development (Erren et al, 2016; Gao et al, 2017; Jarzynski et al, 2017; Jayasekara et al, 2018)
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