No. 3 Vol. 42, No. 4, pp. 297–304, 2008 Development of pre‐paration solubilized coenzyme Q10 with polyglycerol fatty acid esters and application for cosmetics

Abstract

Polyglycerol fatty acid esters (PGFE) , a food grade emulsifier has been used in cosmetic products in recent years due to its safety and low stimulation of skin. Cosmetic formulation containing CoQ1O to provide a stable and clear pre‐paration is difficult because it has a high crystalline property. We have tried the development of CoQ10‐soluble pre‐paration with PGFE applied for cosmetics. The present study is summarized as follows: This CoQ10‐soluble pre‐paration has a bicontinuous microemulsion structure that provides high solubilization capacity and thermodynamic stability. Cosmetics using this CoQ1O soluble pre‐paration tend to improve the skin permeability and also to involve the change in skin conditions (moisturization and elasticity), compared to the non‐bicontinuous microemulsion pre‐paration.Keywords: coenzyme Q10, solubilization, bicontinuous, microemulsion, polyglycerol fatty acid ester, cosmetics, food, emulsifier, safety, low stimulation, skin, moisturization, elasticity