Abstract
Direct access to non‐hydrolyzable glycoconjugates is highly mandatory for stabilizing their intrinsic biological or physical‐chemistry properties in the surrounding environment. Here, a simple and versatile approach for the preparation of multifunctional clickable β‐C‐glycoconjugates has been developed. Readily accessible N,N′‐disubstituted barbituric acids have been synthesized and ligated in water to the reducing end of unprotected carbohydrates via Knoevenagel condensation. Additionally, divalent glycoclusters have been built from bis‐urea backbones and showed ability to interact with a model lectin, the peanut agglutinin. This concept can be readily adapted for the preparation of other C‐glycoconjugates applicable in diverse area of glycosciences.
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