Abstract
Sequence specific recognition of double stranded DNA by oligonucleotides is an important process for selective control of gene expression. However, triple-helix formation is limited to recognition of DNA homopurine strands. We report herein the NMR recognition studies of C•G base pairs by new heterocyclic systems like benzimidazole and benzoxazoles bearing an urea donor function designed to bound to the O4 and N7 atoms of guanosine base.
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