Abstract
<h2>Abstract:</h2> Sonicated dispersions of phosphatidylcholine, lysophosphatidylcholine, phosphatidylinositol, and phosphatidylserine in deuterium oxide were studied by NMR, and the changes in spectra produced on addition of penicillin G and ampicillin to the dispersions were observed. The antibiotics appeared to reduce the configurational freedom and kinetic motion of the phospholipid hydrocarbon chains due to hydrophobic interaction between the hydrocarbon chains and the phenyl portion of the antibiotic side chain. Penicillin G interacted with the phospholipid systems to a greater degree than ampicillin, while the phospholipids interacted in the order phosphatidylserine > phosphatidylcholine > phosphatidylinositol > lysophosphatidylcholine.
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