Abstract
The penetration of ampicillin molecule into the β-cyclodextrin cavity in aqueous solution is studied by 1 H NMR, 2D COSY and ROESY spectroscopy. Obtained data suggest that the phenyl moiety of ampicillin is included inside the hydrophobic cavity of β-cyclodextrin molecule in the solution, and the mode and depth of this inclusion is confirmed on the basis of 2D ROESY spectral data.
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