Abstract
AbstractThe development of sensitive probes for directly measuring in vivo processes is at the forefront of medical imaging. In the case of magnetic resonance imaging (MRI) the detection of a small number of molecules is a major challenge due to its limited sensitivity. This problem can be tackled by hyperpolarization, which increases the NMR signals up to several orders of magnitude. In this contribution NMR hyperpolarization of non‐radioactive counterparts of two well‐established positron emission tomography (PET) tracers, namely O‐(2‐[18F]fluoroethyl)‐l‐tyrosine ([18F]FET) and [18F]fallypride ([18F]FP), via para‐hydrogen induced polarization (PHIP), to investigate oncological and neurological questions is demonstrated. Significant 1H/13C NMR signal enhancements of several thousand were achieved for both tracers. Partial deuteration of the 13C‐labeled [18F]FET analog resulted in T1 times up to ∼36 s. Hence, this molecule is a candidate for an MRI contrast agent, allowing follow‐up MRI examinations with close succession in time.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
