Abstract
Calexcitin (CE) is a Ca 2+-binding protein which is expressed in neuronal cells and is a member of the sarcoplasmic Ca 2+-binding protein subfamily. The peptide backbone of Ca 2+-CE has been assigned by NMR and it shows that CE is composed of nine α-helices—forming four EF-hands and an additional helix near the C-terminus. A structural model of CE suggests the presence of a putative recessed hydrophobic pocket that may be involved in Ca 2+-mediated protein–ligand interactions. This feature is unique to CE and is absent in other SCPs, such as those from Branchiostoma and Nereis, and from calerythrin.
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