Abstract
The prevalence of obesity is rapidly increasing and is recognized as a serious health problem. To investigate metabolic changes in an obese model after administration of Acanthopanax sessiliflorus, mice were divided into four groups: normal diet, high-fat diet (HFD), HFD with treatment fenofibrate, and A. sessiliflorus fruit extract. The liver tissue of mice was analyzed using nuclear magnetic resonance (NMR) spectrometry-based metabolomics. In multivariate statistical analyses, the HFD group was discriminated from the normal diet group, and the group fed A. sessiliflorus fruit was discriminated from the HFD group. In biomarker analysis between the HFD group and the group fed A. sessiliflorus fruit, alanine, inosine, formate, pyroglutamate, taurine, and tyrosine, with AUC values of 0.7 or more, were found. The levels of these metabolites were distinguished from the HFD mouse model. Changes in these metabolites were confirmed to act on metabolic pathways related to antioxidant activity.
Highlights
Accepted: July 2021Obesity, defined as having a body mass index (BMI) ≥ kg/m2 [1], is a complex and multifactorial syndrome
The results of this paper provide further evidence to understand the mechanism of the anti-obesity effect of A
Animal experiments were conducted by dividing the models into four groups: ICR male mice with normal diet (ND) were the control group (G1), high-fat diet (HFD)-induced mice were a negative control group (G2), and HFD-induced mice were treated with fenofibrate (G3) and A. sessiliflorus fruit extract (G4)
Summary
Accepted: July 2021Obesity, defined as having a body mass index (BMI) ≥ kg/m2 [1], is a complex and multifactorial syndrome. Lifestyle (such as dietary habits and physical activity patterns), and their interactions are involved in the prevalence of obesity [2] The prevalence of obesity is increasing rapidly and has been identified as the cause of various chronic diseases, such as cardiovascular disease, cancer, noninsulin-dependent diabetes, and metabolic syndromes [3,4]. Both surgical approaches and non-surgical approaches, including behavior/lifestyle modification and pharmacotherapy, are recommended as treatment options for obesity [5]. Pharmacotherapy may help patients who find it difficult to begin physical activity and modify their lifestyle [8]
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