Abstract
Isolation and purification procedures for the bicyclic oxygenated taxane canadensene, obtained from Taxus canadensis are reported. Molecular modeling studies of canadensene, baccatin III (the core structure of paclitaxel), paclitaxel, taxa-4(5),11(12)-diene (the biosynthetic precursor of paclitaxel) and putative derivatives were performed. NMR constraints were obtained for canadensene and baccatin III. A striking U-shape for canadensene was obtained in the 3D-model. Biosynthetic pathways for the formation of canadensene are proposed.
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