Abstract
The interaction of 2methyl(ethyl)5H(chloro, nitro)benzimidazoles with benzoyl (acetyl) chloride, and ptoluenesulfonyl chloride in the presence of triethylamine in tetrahydrofuran or chloroform was studied. It was found that the reaction proceeds in three stages with the formation of N monobenzoyl (acetyl, ptoluenesulfonyl), N, Cdibenzoyl and N, C, Otribenzoyl benzimidazoles depending on the ratio of reagents, the nature of the substituent in the aromatic ring, αmethylene group, and acid chlorides. It was revealed that in the case of acetyl, ptoluenesulfonyl chloride reaction is stopped at the first stage with formation of Nmonoacetyl (ptoluenesulfonyl) derivatives. The method for HPLC analysis for separation, identification and determination of the ratio of obtained compounds was developed. It was found that 1acetyl (benzoyl)2methylbenzimidazoles Original Research Article Shakhidoyato et al.; ACSj, 6(4): 192-204, 2015; Article no.ACSj.2015.051 193 were decomposed at the standing. The crystalline form of 1acetyl2methylbenzimidazole is decomposed to the 2methylbenzimidazole: 25% (7 days), 50% (15 days), 100% (30 days) and decomposition of 1benzoyl2methylbenzimidazole to the 2methylbenzimidazole (50%) occurs within 2 months.
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